|
Coronary Arteriosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
It is a very important observation, however, because genetic influences are not likely to be confounded by other factors linked with both coronary heart disease and diminished paraoxonase 1 activity.
|
12151850 |
2002 |
|
Coronary Arteriosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
High PON1 activity connected with the presence of CC and CT genotypes decreases the recurrence of symptoms of coronary heart disease and improve prognosis after CABG.
|
24721823 |
2014 |
|
Coronary Arteriosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The current results strongly suggest that Zn may have a protective effect in non-coronary atherosclerosis and indicate that this element may exert its anti-inflammatory and antioxidant functions through interactions with PON1 activity.
|
29525848 |
2018 |
|
Coronary Arteriosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The correlation of homocysteine-thiolactonase activity of the paraoxonase (PON1) protein with coronary heart disease status.
|
17543199 |
2006 |
|
Coronary Arteriosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Low serum PON1 activity: an independent risk factor for coronary artery disease in North-West Indian type 2 diabetics.
|
22333293 |
2012 |
|
Coronary Arteriosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Low serum paraoxonase 1 (PON1) activity determined with paraoxon as substrate has been found to be associated with coronary artery disease.
|
16729301 |
2006 |
|
Coronary Arteriosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A common polymorphism of the PON1 gene, the PON1-192 genetic polymorphism, modulates PON1 activity and has been related in some studies to coronary heart disease.
|
11395042 |
2001 |
|
Coronary Arteriosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Low protective PON1 lactonase activity in an Arab population with high rates of coronary heart disease and diabetes.
|
25801214 |
2015 |
|
Coronary Arteriosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Significant correlations between diabetes mellitus and paraoxonase activity (<i>R =</i> ⁻0.264, <i>p =</i> 0.026) and between the premature coronary heart disease in family history and PON1 activity (<i>R =</i> ⁻0.293, <i>p =</i> 0.013) were found.
|
30935088 |
2019 |
|
Coronary Arteriosclerosis
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Association of PON1 gene promoter DNA methylation with the risk of Clopidogrel resistance in patients with coronary artery disease.
|
30891852 |
2019 |
|
Coronary Arteriosclerosis
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Paraoxonase polymorphism (Gln192-Arg) is associated with coronary heart disease in Japanese noninsulin-dependent diabetes mellitus.
|
9215303 |
1997 |
|
Coronary Arteriosclerosis
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Paraoxonase 1 (PON1) polymorphisms, haplotypes and activity in predicting cad risk in North-West Indian Punjabis.
|
21629682 |
2011 |
|
Coronary Arteriosclerosis
|
0.400 |
Therapeutic
|
disease |
CTD_human |
A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease.
|
8675673 |
1995 |
|
Coronary Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Paraoxonase 1 (PON1) was implicated in susceptibility to coronary artery disease and stroke in previous studies.
|
16239632 |
2005 |
|
Coronary Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
PON1 and PON2 have attracted considerable attention as candidate genes for coronary heart disease because their enzymes function as key factors in lipoprotein catabolism pathways.
|
23053877 |
2013 |
|
Coronary Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Paraoxonase polymorphism (Gln192-Arg) is associated with coronary heart disease in Japanese noninsulin-dependent diabetes mellitus.
|
9215303 |
1997 |
|
Coronary Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Paraoxonase 1 (PON1) polymorphisms, haplotypes and activity in predicting cad risk in North-West Indian Punjabis.
|
21629682 |
2011 |
|
Coronary Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients.
|
18634772 |
2008 |
|
Coronary Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review is focused on the role of PON1 status in different atherosclerosis-related diseases that we have studied over the last twenty years (coronary heart disease, acute ischemic stroke, diabetes mellitus type 2, end-stage renal disease, chronic obstructive pulmonary disease, and sarcoidosis) with the aim to determine the true value of PON1 as a biomarker.
|
31400246 |
2019 |
|
Coronary Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease.
|
8675673 |
1995 |
|
Coronary Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Unexpectedly higher diazoxon hydrolysis by serum paraoxonase-1 in coronary heart disease.
|
30659791 |
2019 |
|
Coronary Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The links between PON1 and Hcy in relation to pathological states such as coronary artery disease, stroke, diabetic mellitus, kidney failure and Alzheimer's disease that emerge from recent studies are the topics of this review.
|
22643843 |
2012 |
|
Coronary Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
R/R genotype of human paraoxonase (PON1) is more protective against lipoprotein oxidation and coronary artery disease in Japanese subjects.
|
12740482 |
2003 |
|
Coronary Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We illustrate the proposed method through three meta-analyses for comparison of prostate cancer treatment, for the association between paraoxonase 1 activities and coronary heart disease, and for the association between homocysteine level and coronary heart disease.
|
25363629 |
2015 |
|
Coronary Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Allelic variants of the human scavenger receptor class B type 1 and paraoxonase 1 on coronary heart disease: genotype-phenotype correlations.
|
15681296 |
2005 |